ABSTRACT
Objective To observe the efficacy of topical indigo naturalis on the serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in Hashimoto's thyroiditis (HT). Methods Sixty-five cases of HT were randomly divided into the treatment group (33 cases) and the control group (32 cases). Hyperthyroidism patients and hypothyroidism patients in the two groups were treated with methimazole 10 mg/d and levothyrocine 25-50 μg/d to control their thyroid function. Based on the basic treatment, patients in the treatment group were treated with topical indigo naturalis local external application, which lasted for 6 months. Results TCM clinical symptoms were improved in both two groups, with statistical significance between the two groups (P<0.05, P<0.01). The efficacy of TCM clinical symptoms was 81.82% (27/33) in the treatment group and 65.63% (21/32) in the control group, with statistical significance (P<0.01). The total effective rate of the treatment group was 84.85% (28/33) and the control group was 71.88%(23/32), with statistical significance between the two groups (P<0.05). Compared with that before treatment, the levels of TGAb and TPOAb were lower in both groups (P<0.05), and with statistical significance between the two groups (P<0.01). Conclusion Indigo naturalis can improve efficacy of treatment for HT, and effectively reduce autoimmune antibodies indicators of thyroid.